Researchers Discover Master Regulator in Cancer Metastasis

Researchers Discover Master Regulator in Cancer Metastasis.

Mammary epithelial cells that have undergone an epithelial-mesenchymal transition (EMT) (left image), exhibit a change in cell morphology with actin stress fibers (red) and with focused cell adhesion points (green). In mammary epithelial cells in which the Sox4 transcription factor is missing (right image), this change is not apparent, and cancer cells cannot metastasize. Image: Nathalie Meyer-Schaller, Univ. of Basel

This article explains the discovery of a “main switch” for cancer metastasis. The research indicates the possibility of preventing/suppressing metastasis through inhibition of the transcription factor at fault. Medications are currently under development.

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